The ideal medication for prevention and treatment of migraine would have no side effects, no risk, would be safe in pregnancy, as well as being highly effective while remaining inexpensive. Of course, no such medication exists, but magnesium comes closer than many interventions on all these fronts. Magnesium oxide is frequently used in pill form to prevent migraine, usually at a dose of 400-500 mg per day.
Results: Migraine days per month declined from 6.2 days during the baseline period to 4.4 days at the end of the treatment with the supplement and from 6.2.days to 5.2 days in the placebo group (p = 0.23 compared to placebo). The intensity of migraine pain was significantly reduced in the supplement group compared to placebo (p = 0.03). The sum score of the HIT-6 questionnaire was reduced by 4.8 points from 61.9 to 57.1 compared to 2 points in the placebo-group (p = 0.01). The evaluation of efficacy by the patient was better in the supplementation group compared to placebo (p = 0.01).
Conclusions: Treatment with a proprietary supplement containing magnesium, riboflavin and Q10 (Migravent®in Germany, Dolovent® in UK/USA) had an impact on migraine frequency which showed a trend towards statistical significance. Migraine symptoms and burden of disease, however, were statistically significantly reduced compared to placebo in patients with migraine attacks.
Keywords: Migraine; Prevention; Nutritional Supplement