Histamine in the body is crucial to us because of its role in an immune response. As it is released, it affects the blood vessels by causing them to dilate and increase permeability which then allows substances such as fluid, white blood cells (leukocytes) and blood plasma proteins to leak from the bloodstream to the area of injury/ infection to fight this infection. This can often be seen as ‘inflammation’ in the localised area.
Although much needed, excess histamine can have a detrimental effect and cause issues in the body. Excess histamine in the gut can cause intolerances and allergy type symptoms which present as symptoms in the skin and other areas of the body.
Histamine can accumulate in the body when the body’s ability to degrade the histamine is out of balance with the amount being accumulated.
Certain foods and drugs can result in an abundance of histamine. Some histamine rich foods are aged cheese, processed meats, wine and beer for example.
Mast cell activation disorder/syndrome (MCAS) can also be responsible for an increase in the amount of histamine in the body. If you have MCAS, your body releases mediators (histamine) too often and frequently.
In a healthy person, the histamine from food is broken down and detoxified quickly by the enzyme diamine oxidase (DAO) in the gastrointestinal tract. DAO is also believed to scavenge extracellular histamine after the mediator release.
In some people, this histamine metabolism does not occur as it should, and these people could be at risk of histamine toxicity.
Excess histamine that is not metabolised effectively in the gastrointestinal tract can be absorbed by the body and circulate causing inflammation in different parts of the body. A lot of the symptoms are similar to an allergic reaction, such as headaches, diarrhoea, nasal congestion, asthmatic wheezing, urticaria to name just a few. These multifaceted symptoms are the reason that histamine intolerance is often underestimated or symptoms misinterpreted.
For those who are histamine sensitive or have reduced DAO activity, symptoms can occur even after ingestion of the smallest amount of histamine. Symptoms can manifest in multiple organs, such as the GI tract, lungs, skin, cardiovascular system and brain.
A healthy diet, avoiding foods such as aged cheese, processed meats and alcohol would help in reducing the amount of histamine, as would ensuring a healthy lifestyle, with healthy food, exercise, avoiding cigarette smoke, pollution and stress.
Toxaprevent Medi Acute contains MANC® which binds and removes excess histamine. The capsules also contain high grade colostrum which acts as an immunomodulator. Colostrum is a complex, nutrient rich, biological fluid which is loaded with immune, growth and tissue repair factors, and helps in the development of immunity. Bovine colostrum is a rich source of immunoglobulins, a class of proteins present in the serum and the cells of the immune system, which function as antibodies. It’s been shown to be actively functional through the digestive tract in humans and a large number of studies have shown that bovine colostrum can prevent gastrointestinal tract infections.
Can also be used in conjunction with Toxaprevent Medi Plus Sachets (See product page).